Negative regulation of calcium ion import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEZT, ARMCX5, and VWF, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion import across plasma membrane activity versus VEZT in LARGE_INTESTINE (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VEZT →	+1.230	+1.596	.003	.003	2	3
STOMACH	ARMCX5 →	-0.693	-1.977	.001	<.001	2	2
LUNG_SCLC	VWF →	+0.765	+0.391	<.001	.007	2	2
LUNG_SCLC	SCHIP1 →	+3.995	+0.391	.004	.007	2	2
BREAST	MLC1 →	+0.145	+1.508	.001	.002	2	2
BREAST	NKX3-2 →	+0.899	+1.508	.006	.002	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905949 vs VEZT — LARGE_INTESTINE

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