Positive regulation of gonad development

Across TCGA patient cohorts, RNA activity of the Positive regulation of gonad development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX3Y, TPD52L2_S161, and GSKIP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gonad development activity versus DDX3Y in PDAC (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DDX3Y →	-1.086	-0.069	.001	<.001	3	4
OV	TPD52L2_S161 →	+1.475	+0.148	<.001	.001	3	3
OV	GSKIP →	-0.400	-0.070	.002	.002	3	3
LUAD	PARN_S623 →	+0.707	+0.101	.006	.002	3	3
OV	PPFIA1_T572 →	+0.961	+0.079	.003	.002	3	3
HNSC	TLE4_S208 →	+0.351	+0.106	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905941 vs DDX3Y — PDAC

Explore this scatter interactively →