Positive regulation of gonad development

Across TCGA cell cohorts, RNA activity of the Positive regulation of gonad development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF608, CLIC1, and OLFML2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF608 grouped by Positive regulation of gonad development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF608 →	-1.693	-0.480	.002	.005	3	4
BLOOD_Leukemia	CLIC1 →	+1.043	+1.404	.002	.001	3	3
LIVER	OLFML2A →	-3.614	-1.521	.003	.002	3	3
PANCREAS	MMAB →	-1.297	-0.312	<.001	.003	2	4
PANCREAS	HSPB8 →	-2.247	-0.568	<.001	.006	3	3
LIVER	PAG1 →	-1.131	-1.002	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF608 by Positive regulation of gonad development activity — OVARY

Explore this box plot interactively →