Regulation of gonad development

Across TCGA patient cohorts, RNA activity of the Regulation of gonad development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DGCR6, MIR5690, and CYP3A5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gonad development activity versus DGCR6 in UCEC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DGCR6 →	+0.258	+0.602	.006	.006	3	3
PDAC	MIR5690 →	-0.920	-0.749	.007	.002	3	3
GBM	CYP3A5 →	+0.351	+0.430	.007	.009	3	3
GBM	NT5DC1 →	-0.604	-0.575	<.001	.001	3	3
GBM	MIR1302-5 →	+0.547	+0.471	.007	.006	3	3
LSCC	HSP90AB2P →	+0.345	+0.630	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905939 vs DGCR6 — UCEC

Explore this scatter interactively →