Regulation of gonad development

Across TCGA cell cohorts, RNA activity of the Regulation of gonad development pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are NU7441, 5-Fluorouracil, and I-BRD9, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NU7441 grouped by Regulation of gonad development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NU7441 →	-0.604	-1.495	.044	.009	1	1
BLOOD_Leukemia	5-Fluorouracil →	-0.709	-1.495	.006	.009	1	1
BLOOD_Leukemia	I-BRD9 →	-0.695	-1.495	.048	.009	1	1
BLOOD_Leukemia	WYE-125132 →	+1.045	+1.495	.012	.009	1	1
BLOOD_Leukemia	Pemetrexed →	-1.660	-1.495	.041	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest associations by consensus.

NU7441 by Regulation of gonad development activity — BLOOD_Leukemia

Explore this box plot interactively →