Regulation of calcium ion export across plasma membrane

Across TCGA patient cohorts, RNA activity of the Regulation of calcium ion export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNRC6B, TRIP11, and NFAT5, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion export across plasma membrane activity versus TNRC6B in UVM (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	TNRC6B →	+0.889	+0.057	<.001	<.001	3	34
UVM	TRIP11 →	+1.487	+0.069	<.001	<.001	3	34
THYM	NFAT5 →	+2.065	+0.044	<.001	<.001	3	34
THYM	BICRAL →	+0.995	+0.040	<.001	<.001	3	34
SCLC	KMT2A →	+1.074	+0.060	<.001	<.001	3	34
UVM	ZSWIM6 →	+1.337	+0.067	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905912 vs TNRC6B — UVM

Explore this scatter interactively →