Regulation of calcium ion export across plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion export across plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALM2, YWHAE, and CALM3, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CALM2 grouped by Regulation of calcium ion export across plasma membrane-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CALM2 →	-0.259	-0.878	<.001	.001	3	14
LUNG_SCLC	YWHAE →	-0.400	-1.160	.009	.006	3	12
BLOOD_Lymphoma	CALM3 →	-0.227	-0.294	.004	.004	2	8
LUNG_NSCLC_LUAD	CALM1 →	-0.111	-0.595	.001	.002	3	5
LUNG_NSCLC_LUSC	CYP4F2 →	+0.258	+1.223	<.001	<.001	3	4
SOFT_TISSUE	SEMA3A →	+0.161	+0.172	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CALM2 by Regulation of calcium ion export across plasma membrane activity — BREAST

Explore this box plot interactively →