Positive regulation of amyloid fibril formation

Across TCGA patient cohorts, RNA activity of the Positive regulation of amyloid fibril formation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL4, RPS24, and RPS3A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amyloid fibril formation activity versus RPL4 in GBM (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL4 →	-0.322	-0.041	<.001	<.001	3	7
GBM	RPS24 →	-0.251	-0.036	.002	.002	3	7
COAD	RPS3A →	-0.272	-0.061	<.001	<.001	3	7
HNSC	SPTBN1_S257 →	+0.481	+0.085	.001	<.001	3	7
LUAD	YME1L1 →	-0.264	-0.062	.002	<.001	3	7
COAD	SORBS2 →	+0.479	+0.054	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905908 vs RPL4 — GBM

Explore this scatter interactively →