Positive regulation of amyloid fibril formation

Across TCGA cell cohorts, RNA activity of the Positive regulation of amyloid fibril formation pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM187, OR52M1, and RCCD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM187 grouped by Positive regulation of amyloid fibril formation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TMEM187 →	+0.120	+1.840	.006	<.001	3	3
BLOOD_Leukemia	OR52M1 →	+0.300	+1.726	.001	<.001	3	3
LUNG_SCLC	RCCD1 →	+0.419	+0.799	<.001	.006	3	3
OESOPHAGUS	CORO2A →	-0.150	-1.260	.002	<.001	3	3
OESOPHAGUS	ACVR1B →	+0.102	+1.464	.009	.001	3	3
KIDNEY	ACIN1 →	+0.290	+1.741	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM187 by Positive regulation of amyloid fibril formation activity — KIDNEY

Explore this box plot interactively →