Negative regulation of amyloid fibril formation

Across TCGA cell cohorts, RNA activity of the Negative regulation of amyloid fibril formation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTP4, TATDN3, and GTF2F1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amyloid fibril formation activity versus RTP4 in PANCREAS (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RTP4 →	-1.551	-1.237	.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	TATDN3 →	+0.698	+1.247	.001	.001	3	6
BONE	GTF2F1 →	+0.684	+0.408	.003	.007	3	5
LUNG_SCLC	TLR6 →	-1.359	-0.250	.008	.001	3	5
LARGE_INTESTINE	PARK7 →	+0.569	+0.923	.006	.006	3	5
UPPER_AERODIGESTIVE_TRACT	METTL21A →	+1.221	+1.482	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905907 vs RTP4 — PANCREAS

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