Regulation of amyloid fibril formation

Across TCGA patient cohorts, RNA activity of the Regulation of amyloid fibril formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOXL2, FN1, and ADAMTS12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amyloid fibril formation activity versus LOXL2 in BRCA (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LOXL2 →	+0.749	+0.097	.003	.009	3	4
BRCA	FN1 →	+0.877	+0.076	.001	.006	3	4
BRCA	ADAMTS12 →	+1.043	+0.132	<.001	<.001	3	4
BRCA	EDNRA →	+0.743	+0.085	<.001	.002	3	4
BRCA	COL5A1 →	+0.765	+0.075	.002	.006	3	4
PDAC	LINC01705 →	+0.799	+0.104	.009	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905906 vs LOXL2 — BRCA

Explore this scatter interactively →