Regulation of amyloid fibril formation

Across TCGA cell cohorts, RNA activity of the Regulation of amyloid fibril formation pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBCA, PFDN1, and PFDN2, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amyloid fibril formation activity versus TBCA in LUNG_NSCLC_LUSC (Pearson r = 0.80).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TBCA →	+2.990	+1.948	.004	.007	3	19
OVARY	PFDN1 →	+2.267	+1.039	<.001	.001	3	19
OVARY	PFDN2 →	+2.358	+1.042	<.001	<.001	3	18
OVARY	ELOC →	+1.275	+1.079	<.001	.003	3	18
URINARY_TRACT	VBP1 →	+2.690	+1.514	.009	.009	2	19
UPPER_AERODIGESTIVE_TRACT	LSM12 →	+1.704	+1.259	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905906 vs TBCA — LUNG_NSCLC_LUSC

Explore this scatter interactively →