Positive regulation of response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Positive regulation of response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC186, SETX, and BIRC6, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of response to endoplasmic reticulum stress activity versus CCDC186 in THYM (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	CCDC186 →	+1.210	+0.050	<.001	<.001	3	33
UVM	SETX →	+1.304	+0.039	<.001	<.001	3	32
UVM	BIRC6 →	+1.198	+0.040	<.001	<.001	3	32
UVM	ARFGEF2 →	+1.367	+0.036	<.001	<.001	3	32
THYM	NCOA2 →	+1.433	+0.052	<.001	<.001	3	32
UVM	ATM →	+1.374	+0.037	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905898 vs CCDC186 — THYM

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