Positive regulation of response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Positive regulation of response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBL7-AS1, PXYLP1, and RSAD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of response to endoplasmic reticulum stress activity versus UBL7-AS1 in LSCC (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBL7-AS1 →	-0.300	-0.158	.002	<.001	3	5
HNSC	PXYLP1 →	-0.551	-0.127	<.001	.005	3	5
HNSC	RSAD1 →	-0.591	-0.195	.001	<.001	3	5
CCRCC	RMDN3 →	-0.194	-0.131	<.001	.001	3	5
CCRCC	SHANK2 →	-0.445	-0.125	<.001	.003	3	5
HNSC	KCNK2 →	-0.692	-0.161	.004	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905898 vs UBL7-AS1 — LSCC

Explore this scatter interactively →