Positive regulation of response to endoplasmic reticulum stress

Across TCGA cell cohorts, RNA activity of the Positive regulation of response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC2, DOCK4, and BCL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of response to endoplasmic reticulum stress activity versus RAC2 in PANCREAS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RAC2 →	+2.971	+0.266	.005	.002	3	5
SKIN	DOCK4 →	+1.193	+0.199	.008	.006	3	5
BLOOD_Myeloma	BCL3 →	+1.522	+0.303	.002	.002	3	5
LUNG_NSCLC_LUSC	SPATS2L →	+1.767	+0.426	.009	.008	3	4
BLOOD_Lymphoma	MLKL →	+1.839	+0.183	.006	<.001	3	4
CNS	IL12RB1 →	+0.634	+0.200	.007	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905898 vs RAC2 — PANCREAS

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