Regulation of response to endoplasmic reticulum stress

Across TCGA cell cohorts, RNA activity of the Regulation of response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN2, UBE2D2, and ISCA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to endoplasmic reticulum stress activity versus CAPN2 in PANCREAS (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CAPN2 →	+1.112	+0.176	.002	.004	3	5
SOFT_TISSUE	UBE2D2 →	-0.570	-0.208	.003	.003	3	4
LUNG_NSCLC_LUSC	ISCA2 →	+0.927	+0.207	.005	.008	3	4
LUNG_NSCLC_LUSC	GPHN →	+1.312	+0.181	.006	.003	3	4
KIDNEY	FIG4 →	+0.702	+0.317	.006	.002	3	4
LUNG_SCLC	PGAP6 →	+0.984	+0.162	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905897 vs CAPN2 — PANCREAS

Explore this scatter interactively →