Regulation of postsynaptic density organization

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic density organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EMILIN2, FMNL1, and GBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic density organization activity versus EMILIN2 in GBM (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EMILIN2 →	+0.437	+0.041	.005	.002	3	8
UCEC	FMNL1 →	+0.449	+0.066	.006	.003	3	8
BRCA	GBP1 →	+0.841	+0.073	<.001	<.001	3	8
LUAD	TBXAS1 →	+0.391	+0.058	<.001	<.001	3	7
UCEC	BIN2 →	+0.492	+0.068	.003	.002	3	7
UCEC	DOCK10 →	+0.445	+0.083	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905874 vs EMILIN2 — GBM

Explore this scatter interactively →