Regulation of postsynaptic density organization

Across TCGA cell cohorts, RNA activity of the Regulation of postsynaptic density organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZEB1, LARGE1, and CRIP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic density organization activity versus ZEB1 in LUNG_NSCLC_LUAD (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZEB1 →	+1.142	+0.122	.002	.007	3	5
BLOOD_Myeloma	LARGE1 →	+1.882	+0.164	<.001	.009	3	4
PANCREAS	CRIP2 →	-4.201	-0.308	<.001	<.001	3	4
LIVER	LARP6 →	+1.269	+0.225	.008	.009	3	4
LUNG_NSCLC_LUAD	LYPD3 →	-2.482	-0.190	.002	.003	3	4
OVARY	ACO1 →	+0.913	+0.255	.009	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905874 vs ZEB1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →