Positive regulation of 3'-UTR-mediated mRNA stabilization

Across TCGA patient cohorts, RNA activity of the Positive regulation of 3'-UTR-mediated mRNA stabilization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA2, ACBD5, and GTPBP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of 3'-UTR-mediated mRNA stabilization activity versus LAMA2 in BRCA (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LAMA2 →	-1.025	-0.459	<.001	<.001	3	6
GBM	ACBD5 →	+0.449	+0.459	.001	.009	3	5
LSCC	GTPBP4 →	+0.555	+0.800	<.001	<.001	3	5
GBM	UPF2 →	+0.287	+0.517	.002	<.001	3	5
BRCA	MFAP4 →	-1.522	-0.531	<.001	<.001	3	5
BRCA	CNRIP1 →	-0.627	-0.624	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905870 vs LAMA2 — BRCA

Explore this scatter interactively →