Positive regulation of 3'-UTR-mediated mRNA stabilization

Across TCGA cell cohorts, RNA activity of the Positive regulation of 3'-UTR-mediated mRNA stabilization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBR1, FUT9, and PPP1R16A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TGFBR1 grouped by Positive regulation of 3'-UTR-mediated mRNA stabilization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TGFBR1 →	+1.645	+1.179	<.001	.004	3	4
URINARY_TRACT	FUT9 →	-1.803	-1.702	.002	<.001	3	4
BREAST	PPP1R16A →	-0.925	-0.690	.003	<.001	1	5
BREAST	OXSR1 →	+0.814	+0.713	.001	.005	3	3
UPPER_AERODIGESTIVE_TRACT	VRK3 →	-0.625	-1.144	.005	.001	3	3
UPPER_AERODIGESTIVE_TRACT	ATP1B1 →	-1.255	-1.326	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TGFBR1 by Positive regulation of 3'-UTR-mediated mRNA stabilization activity — BLOOD_Leukemia

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