Positive regulation of 3'-UTR-mediated mRNA stabilization

Across TCGA cell cohorts, RNA activity of the Positive regulation of 3'-UTR-mediated mRNA stabilization pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are AZ20, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AZ20 grouped by Positive regulation of 3'-UTR-mediated mRNA stabilization-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AZ20 →	+0.550	+0.257	.014	.015	1	1

Each partner links to its Q-omics profile. Showing the 1 strongest associations by consensus.

AZ20 by Positive regulation of 3'-UTR-mediated mRNA stabilization activity — LUNG_SCLC

Explore this box plot interactively →