Regulation of 3'-UTR-mediated mRNA stabilization

Across TCGA patient cohorts, RNA activity of the Regulation of 3'-UTR-mediated mRNA stabilization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSE1_S1101, CFDP1, and DHX38, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of 3'-UTR-mediated mRNA stabilization activity versus GSE1_S1101 in GBM (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GSE1_S1101 →	+0.736	+0.072	<.001	<.001	3	6
LSCC	CFDP1 →	+0.257	+0.046	<.001	.001	3	6
LSCC	DHX38 →	+0.163	+0.056	<.001	<.001	3	5
LSCC	WWP2 →	+0.207	+0.049	<.001	<.001	3	5
LSCC	ANK2_S3845 →	-0.749	-0.059	<.001	.002	3	5
LSCC	AP1G1 →	+0.109	+0.041	.001	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905868 vs GSE1_S1101 — GBM

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