Regulation of 3'-UTR-mediated mRNA stabilization

Across TCGA patient cohorts, RNA activity of the Regulation of 3'-UTR-mediated mRNA stabilization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LARP4B, SLC9A7_S693, and TGFB1I1_S164, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of 3'-UTR-mediated mRNA stabilization activity versus LARP4B in BRCA (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LARP4B →	+0.401	+0.534	<.001	.005	3	4
OV	SLC9A7_S693 →	-1.229	-0.702	<.001	.003	3	4
CCRCC	TGFB1I1_S164 →	-0.611	-0.466	.002	.003	2	4
CCRCC	TNS2_S1003 →	-0.706	-0.806	<.001	<.001	3	3
BRCA	SMPD1 →	-0.421	-0.751	<.001	<.001	3	3
UCEC	TNS2_S648 →	-0.521	-0.489	.002	.007	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905868 vs LARP4B — BRCA

Explore this scatter interactively →