Regulation of 3'-UTR-mediated mRNA stabilization

Across TCGA cell cohorts, RNA activity of the Regulation of 3'-UTR-mediated mRNA stabilization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QKI, RFLNB, and TBC1D30, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of 3'-UTR-mediated mRNA stabilization activity versus QKI in OVARY (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	QKI →	+1.632	+0.991	.001	.003	3	6
LUNG_SCLC	RFLNB →	+1.362	+0.822	.003	.005	3	5
STOMACH	TBC1D30 →	-2.653	-1.362	.001	<.001	3	5
STOMACH	ENTPD2 →	-2.347	-1.138	.002	<.001	3	5
BLOOD_Myeloma	KCNK1 →	-3.960	-1.322	<.001	.002	3	4
LUNG_NSCLC_LUSC	OVOL2 →	-2.046	-1.002	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905868 vs QKI — OVARY

Explore this scatter interactively →