Positive regulation of spindle assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUMA1, PKP4, and LRTOMT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of spindle assembly activity versus NUMA1 in HNSC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NUMA1 →	+0.979	+1.252	<.001	<.001	3	5
HNSC	PKP4 →	+0.435	+0.486	.003	.004	3	5
LSCC	LRTOMT →	+0.625	+0.575	<.001	<.001	3	5
HNSC	RN7SL239P →	+0.935	+0.684	<.001	.001	3	5
HNSC	OR7E126P →	+0.964	+0.867	.001	<.001	3	5
COAD	PIKFYVE →	+0.421	+0.408	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905832 vs NUMA1 — HNSC

Explore this scatter interactively →