Positive regulation of spindle assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSRC1, GPSM2, and KIF2C, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of spindle assembly activity versus PSRC1 in SOFT_TISSUE (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PSRC1 →	+1.310	+0.128	<.001	<.001	3	19
LUNG_SCLC	GPSM2 →	+1.317	+0.150	<.001	<.001	3	17
KIDNEY	KIF2C →	+1.138	+0.148	<.001	<.001	3	16
STOMACH	CCDC18 →	+1.380	+0.112	<.001	.002	3	15
KIDNEY	KIF14 →	+0.833	+0.107	<.001	.003	3	15
URINARY_TRACT	SPAG5 →	+1.392	+0.120	<.001	.004	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905832 vs PSRC1 — SOFT_TISSUE

Explore this scatter interactively →