Positive regulation of chromosome separation

Across TCGA cell cohorts, RNA activity of the Positive regulation of chromosome separation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND5A, AUTS2, and SETD1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chromosome separation activity versus DENND5A in URINARY_TRACT (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DENND5A →	+1.656	+1.797	.007	<.001	3	7
BLOOD_Lymphoma	AUTS2 →	+2.430	+1.119	.002	<.001	3	6
BLOOD_Leukemia	SETD1A →	+0.493	+0.750	.001	.004	3	6
BLOOD_Leukemia	PDXP →	+0.742	+1.116	<.001	<.001	3	6
BLOOD_Leukemia	CCNG2 →	+1.108	+1.165	.003	<.001	3	6
BLOOD_Leukemia	HMGB2 →	+0.809	+0.978	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905820 vs DENND5A — URINARY_TRACT

Explore this scatter interactively →