Negative regulation of synapse organization

Across TCGA patient cohorts, RNA activity of the Negative regulation of synapse organization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGB4, TLR2, and TNKS1BP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of synapse organization activity versus ITGB4 in HNSC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ITGB4 →	+0.542	+0.077	<.001	.001	3	7
HNSC	TLR2 →	+0.468	+0.107	<.001	<.001	3	6
BRCA	TNKS1BP1 →	+0.224	+0.059	.002	<.001	3	6
PDAC	RIC8A →	+0.145	+0.076	.001	.004	3	5
HNSC	BACH1 →	+0.263	+0.077	<.001	.003	3	5
LUAD	TNKS1BP1_S672 →	+0.326	+0.112	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905809 vs ITGB4 — HNSC

Explore this scatter interactively →