Negative regulation of synapse organization

Across TCGA patient cohorts, RNA activity of the Negative regulation of synapse organization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN13, ADAMDEC1, and FGD6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of synapse organization activity versus PTPN13 in LUAD (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PTPN13 →	+1.515	+0.605	<.001	<.001	3	9
HNSC	ADAMDEC1 →	-1.119	-0.309	<.001	.002	3	5
PDAC	FGD6 →	+0.558	+0.180	<.001	.001	3	5
LUAD	CRTAP →	+0.254	+0.366	.005	.007	2	6
LUAD	SORCS2 →	+0.903	+0.523	<.001	<.001	3	5
HNSC	CEP128 →	-0.678	-0.438	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905809 vs PTPN13 — LUAD

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