Negative regulation of synapse organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of synapse organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSAD, HECTD2, and CREB3L4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSAD grouped by Negative regulation of synapse organization-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CSAD →	+1.268	+0.938	.001	<.001	3	5
STOMACH	HECTD2 →	+1.126	+1.205	.002	.002	3	5
BLOOD_Leukemia	CREB3L4 →	+0.920	+0.978	<.001	.001	3	5
OVARY	NSFL1C →	-0.927	-1.350	<.001	<.001	3	5
LIVER	PCGF2 →	+1.013	+1.363	.004	.001	3	4
BLOOD_Myeloma	C2orf76 →	+0.696	+1.230	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSAD by Negative regulation of synapse organization activity — BREAST

Explore this box plot interactively →