Regulation of synapse pruning

Across TCGA patient cohorts, RNA activity of the Regulation of synapse pruning pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARPC5, ITGAX, and PLCB2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synapse pruning activity versus ARPC5 in LSCC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARPC5 →	+0.217	+0.090	<.001	<.001	3	8
UCEC	ITGAX →	+0.510	+0.088	.001	.003	3	7
LSCC	PLCB2 →	+0.327	+0.081	<.001	<.001	3	7
BRCA	DNAJC19 →	-0.508	-0.059	<.001	.001	3	7
GBM	PLXNC1 →	+0.407	+0.082	<.001	<.001	3	7
LSCC	POLR3A →	-0.214	-0.101	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905806 vs ARPC5 — LSCC

Explore this scatter interactively →