Regulation of endosome to plasma membrane protein transport

Across TCGA patient cohorts, RNA activity of the Regulation of endosome to plasma membrane protein transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLIC2, GIMAP7, and SEPTIN6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endosome to plasma membrane protein transport activity versus CLIC2 in LSCC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLIC2 →	+0.564	+0.074	<.001	<.001	3	7
HNSC	GIMAP7 →	+0.550	+0.087	<.001	<.001	3	7
HNSC	SEPTIN6 →	+0.423	+0.075	<.001	<.001	3	6
LSCC	DPYSL2 →	+0.494	+0.085	<.001	<.001	3	6
HNSC	EVL →	+0.708	+0.075	<.001	<.001	3	6
UCEC	AP3B2_S272 →	+0.741	+0.043	.003	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905749 vs CLIC2 — LSCC

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