Protein localization to perinuclear region of cytoplasm

Across TCGA cell cohorts, RNA activity of the Protein localization to perinuclear region of cytoplasm pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNN4, PER1, and SMARCD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNN4 grouped by Protein localization to perinuclear region of cytoplasm-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KCNN4 →	+2.776	+1.377	.002	.004	2	5
LIVER	PER1 →	-0.962	-1.138	.009	.002	3	4
BLOOD_Leukemia	SMARCD1 →	-1.567	-1.953	<.001	<.001	3	4
PANCREAS	ERLIN1 →	+1.067	+1.315	<.001	<.001	3	4
LUNG_NSCLC_LUSC	N4BP2 →	-0.930	-1.940	<.001	<.001	3	4
LARGE_INTESTINE	ULK3 →	-0.670	-0.912	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNN4 by Protein localization to perinuclear region of cytoplasm activity — OESOPHAGUS

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