Protein localization to perinuclear region of cytoplasm

Across TCGA cell cohorts, RNA activity of the Protein localization to perinuclear region of cytoplasm pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQSTM1, CD68, and FTL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to perinuclear region of cytoplasm activity versus SQSTM1 in OESOPHAGUS (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SQSTM1 →	+1.663	+0.586	<.001	.001	3	5
OESOPHAGUS	CD68 →	+2.699	+0.451	.009	.002	3	5
LUNG_NSCLC_LUAD	FTL →	+1.654	+0.256	.004	.002	3	5
LUNG_NSCLC_LUSC	F2RL2 →	+3.530	+0.431	<.001	.003	3	4
LUNG_SCLC	DHX57 →	-0.577	-1.062	.002	.001	3	4
SKIN	BAG4 →	-0.580	-0.221	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905719 vs SQSTM1 — OESOPHAGUS

Explore this scatter interactively →