Lipid droplet disassembly

Across TCGA patient cohorts, RNA activity of the Lipid droplet disassembly pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLIN2, GIMAP5, and TNFSF8, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid droplet disassembly activity versus PLIN2 in MESO (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	PLIN2 →	+1.666	+0.080	<.001	<.001	3	27
DLBC	GIMAP5 →	+1.392	+0.064	<.001	<.001	3	27
DLBC	TNFSF8 →	+2.070	+0.075	<.001	<.001	3	26
DLBC	ETS1 →	+1.202	+0.086	<.001	<.001	3	26
DLBC	PTPRC →	+1.614	+0.079	<.001	<.001	3	26
DLBC	CSF2RB →	+1.200	+0.062	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905691 vs PLIN2 — MESO

Explore this scatter interactively →