Lipid droplet disassembly

Across TCGA patient cohorts, RNA activity of the Lipid droplet disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKAA2, PRKAA2_S377, and ARHGEF16, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid droplet disassembly activity versus PRKAA2 in LUAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRKAA2 →	+0.571	+0.048	<.001	<.001	3	5
LSCC	PRKAA2_S377 →	+0.833	+0.068	<.001	.001	2	6
PDAC	ARHGEF16 →	+0.391	+0.038	.002	.007	3	5
BRCA	SNX15 →	+0.138	+0.036	.001	<.001	3	4
LSCC	BICD2 →	-0.368	-0.041	.007	.007	3	4
UCEC	ADPRS →	+0.188	+0.069	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905691 vs PRKAA2 — LUAD

Explore this scatter interactively →