Lipid droplet disassembly

Across TCGA patient cohorts, RNA activity of the Lipid droplet disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAA2, AKT3, and GDAP1L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid droplet disassembly activity versus PRKAA2 in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKAA2 →	+1.146	+0.509	<.001	<.001	3	4
PDAC	AKT3 →	-0.321	-0.171	.007	.006	3	3
LUAD	GDAP1L1 →	-0.496	-0.161	<.001	.001	3	3
PDAC	ARHGEF9 →	-0.257	-0.183	.002	<.001	3	3
PDAC	FTO →	-0.185	-0.173	<.001	<.001	3	3
PDAC	SMAD4 →	-0.259	-0.171	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905691 vs PRKAA2 — BRCA

Explore this scatter interactively →