Regulation of plasma membrane repair

Across TCGA patient cohorts, RNA activity of the Regulation of plasma membrane repair pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASP7, IFI35, and TRIM21, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasma membrane repair activity versus CASP7 in UCEC (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CASP7 →	+0.467	+0.075	<.001	<.001	3	8
HNSC	IFI35 →	+0.423	+0.051	<.001	.009	3	6
HNSC	TRIM21 →	+0.637	+0.083	<.001	<.001	3	6
LSCC	NMI →	+0.314	+0.043	<.001	<.001	3	6
LSCC	CASP7_S37 →	+0.636	+0.047	<.001	<.001	3	5
PDAC	PHACTR2 →	+0.307	+0.037	.002	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905684 vs CASP7 — UCEC

Explore this scatter interactively →