Regulation of plasma membrane repair

Across TCGA cell cohorts, RNA activity of the Regulation of plasma membrane repair pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH2B3, KIAA0513, and SLC35A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SH2B3 grouped by Regulation of plasma membrane repair-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SH2B3 →	-1.031	-0.972	.007	.006	3	4
OESOPHAGUS	KIAA0513 →	-1.216	-1.796	.005	<.001	3	4
BREAST	SLC35A1 →	+0.846	+0.817	<.001	<.001	3	4
KIDNEY	BCL10 →	-0.785	-1.155	<.001	.001	2	5
BREAST	GSE1 →	+1.453	+0.971	<.001	<.001	3	4
BREAST	LRSAM1 →	+0.712	+1.007	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SH2B3 by Regulation of plasma membrane repair activity — SKIN

Explore this box plot interactively →