Regulation of plasma membrane repair

Across TCGA cell cohorts, RNA activity of the Regulation of plasma membrane repair pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, LMNA, and S100A10, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasma membrane repair activity versus ANXA2 in LUNG_SCLC (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANXA2 →	+3.965	+0.541	<.001	<.001	3	13
BLOOD_Lymphoma	LMNA →	+3.720	+0.316	<.001	<.001	3	10
BONE	S100A10 →	+3.154	+0.278	.005	.001	3	9
BLOOD_Lymphoma	AHNAK →	+3.949	+0.285	<.001	<.001	3	9
BONE	THBS1 →	+5.452	+0.299	.003	.003	3	8
LIVER	BLZF1 →	+0.960	+0.343	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905684 vs ANXA2 — LUNG_SCLC

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