Regulation of lysosome organization

Across TCGA patient cohorts, RNA activity of the Regulation of lysosome organization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL38, UBA52, and DDX21, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lysosome organization activity versus RPL38 in HNSC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL38 →	-0.188	-0.067	.007	.009	3	7
HNSC	UBA52 →	-0.227	-0.053	.004	.004	3	6
BRCA	DDX21 →	-0.379	-0.040	.001	<.001	3	5
BRCA	AKAP12_S514 →	+0.962	+0.047	.008	.005	3	5
BRCA	ALAD →	+0.373	+0.046	<.001	.001	3	5
BRCA	GSN →	+0.389	+0.034	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905671 vs RPL38 — HNSC

Explore this scatter interactively →