Regulation of lysosome organization

Across TCGA cell cohorts, RNA activity of the Regulation of lysosome organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISG15, ANXA6, and DICER1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ISG15 grouped by Regulation of lysosome organization-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ISG15 →	-1.727	-0.722	.005	.002	3	4
BREAST	ANXA6 →	+2.655	+0.872	<.001	.001	3	4
SKIN	DICER1 →	-0.448	-0.385	.003	.005	3	3
URINARY_TRACT	IL27RA →	-1.658	-0.260	<.001	.001	3	3
URINARY_TRACT	OSER1 →	+0.775	+0.260	<.001	.001	3	3
URINARY_TRACT	TENM3 →	-3.160	-0.303	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ISG15 by Regulation of lysosome organization activity — BREAST

Explore this box plot interactively →