Regulation of lysosome organization

Across TCGA cell cohorts, RNA activity of the Regulation of lysosome organization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLCN, MCOLN1, and FNIP1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lysosome organization activity versus FLCN in LIVER (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FLCN →	+1.613	+0.150	<.001	<.001	3	18
SKIN	MCOLN1 →	+1.294	+0.132	<.001	<.001	3	17
STOMACH	FNIP1 →	+1.102	+0.131	<.001	<.001	3	16
STOMACH	PLEKHM2 →	+1.066	+0.129	.004	<.001	3	15
STOMACH	ZSWIM8 →	+1.150	+0.156	<.001	<.001	3	13
BLOOD_Lymphoma	SLC38A7 →	+0.920	+0.082	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905671 vs FLCN — LIVER

Explore this scatter interactively →