Regulation of lysosome organization

Across TCGA cell cohorts, RNA activity of the Regulation of lysosome organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARB2, CFLAR, and ADPGK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lysosome organization activity versus SCARB2 in BLOOD_Lymphoma (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SCARB2 →	+2.993	+0.996	<.001	.002	3	8
BLOOD_Myeloma	CFLAR →	+2.495	+1.690	.003	<.001	3	5
BLOOD_Myeloma	ADPGK →	+1.450	+1.865	.003	.003	3	4
BLOOD_Myeloma	BTBD9 →	+1.109	+1.709	.001	<.001	3	4
OESOPHAGUS	EZR →	+2.223	+1.263	.003	<.001	3	4
BREAST	LRIT3 →	+0.340	+1.094	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905671 vs SCARB2 — BLOOD_Lymphoma

Explore this scatter interactively →