Regulation of protein localization to endosome

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to endosome pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPYD-IT1, RPL32P1, and CSF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to endosome activity versus DPYD-IT1 in LSCC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DPYD-IT1 →	+0.759	+0.230	<.001	.002	3	5
LSCC	RPL32P1 →	+0.698	+0.287	.002	.001	3	4
LSCC	CSF1 →	+0.709	+0.214	<.001	.005	3	4
LSCC	SLC34A2 →	+1.670	+0.270	<.001	.003	3	4
UCEC	MILR1 →	+1.046	+0.255	<.001	<.001	3	4
GBM	SAA2 →	+1.686	+0.350	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905666 vs DPYD-IT1 — LSCC

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