Positive regulation of calcium ion import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcium ion import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPTBN1, TESPA1_S311, and ANK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion import across plasma membrane activity versus SPTBN1 in GBM (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPTBN1 →	+0.260	+0.068	.004	.001	3	6
LSCC	TESPA1_S311 →	+0.786	+0.127	<.001	<.001	3	6
HNSC	ANK2 →	+0.617	+0.081	<.001	<.001	3	6
LSCC	MDM1_T515 →	+0.521	+0.093	<.001	<.001	3	6
LSCC	PRKCB →	+0.574	+0.127	<.001	<.001	3	6
LSCC	RASIP1_S41 →	+0.637	+0.138	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905665 vs SPTBN1 — GBM

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