Positive regulation of calcium ion import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8A1, TESPA1, and WAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion import across plasma membrane activity versus ATP8A1 in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ATP8A1 →	+1.122	+0.926	<.001	<.001	3	5
GBM	TESPA1 →	+0.815	+0.408	<.001	<.001	3	5
LSCC	WAS →	+0.767	+0.879	<.001	<.001	3	5
LSCC	BTD →	+0.196	+0.498	.004	.004	3	5
LSCC	GNG7 →	+0.364	+0.741	<.001	<.001	3	5
HNSC	PLD4 →	+0.779	+0.818	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905665 vs ATP8A1 — LSCC

Explore this scatter interactively →