Positive regulation of calcium ion import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPA2, EME1, and PCSK7, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion import across plasma membrane activity versus HSPA2 in CNS (Pearson r = -0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HSPA2 →	-2.860	-1.674	.008	<.001	3	3
CNS	EME1 →	+0.566	+1.674	.005	<.001	3	3
BREAST	PCSK7 →	-0.913	-1.496	.007	<.001	3	2
BREAST	PGM2L1 →	-1.803	-1.496	.002	<.001	3	2
BREAST	MIS12 →	+0.820	+1.496	.009	<.001	3	2
BREAST	TRMT112 →	+1.083	+1.496	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905665 vs HSPA2 — CNS

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