Proline import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Proline import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM1_S797, NFIL3_S286, and CCSAP_S240, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proline import across plasma membrane activity versus SRRM1_S797 in LUAD (Pearson r = 0.81).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SRRM1_S797 →	+2.288	+0.271	.001	.006	3	5
HNSC	NFIL3_S286 →	+0.446	+0.088	<.001	.001	3	5
LUAD	CCSAP_S240 →	-0.256	-0.062	<.001	<.001	3	4
HNSC	ADPRH →	-0.316	-0.078	.003	.002	3	4
LUAD	EIF4B_S459 →	+0.392	+0.075	.002	.002	3	4
LUAD	EIF4B_S93 →	+0.656	+0.094	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905647 vs SRRM1_S797 — LUAD

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