Proline import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Proline import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTN1, MFSD14A, and ZNF407, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proline import across plasma membrane activity versus RTN1 in LSCC (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RTN1 →	-1.116	-0.240	.003	.008	3	4
HNSC	MFSD14A →	-0.892	-0.657	.007	.001	3	3
HNSC	ZNF407 →	-0.671	-0.950	.003	<.001	3	3
PDAC	WIPF2 →	-0.508	-0.332	.006	.001	3	3
PDAC	NBR1 →	-0.398	-0.325	.005	.001	3	3
GBM	DLG5 →	-0.622	-0.170	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905647 vs RTN1 — LSCC

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